Cargando…

Label-free identification of protein aggregates using deep learning

Protein misfolding and aggregation play central roles in the pathogenesis of various neurodegenerative diseases (NDDs), including Huntington’s disease, which is caused by a genetic mutation in exon 1 of the Huntingtin protein (Httex1). The fluorescent labels commonly used to visualize and monitor th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibrahim, Khalid A., Grußmayer, Kristin S., Riguet, Nathan, Feletti, Lely, Lashuel, Hilal A., Radenovic, Aleksandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684545/ https://www.ncbi.nlm.nih.gov/pubmed/38016971 http://dx.doi.org/10.1038/s41467-023-43440-7

Ejemplares similares

Parameter-free rendering of single-molecule localization microscopy data for parameter-free resolution estimation
por: Descloux, Adrien C., et al.
Publicado: (2021)

Monitoring alpha‐synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get
por: Frey, Bryan, et al.
Publicado: (2020)

Non-monotonic fibril surface occlusion by GFP tags from coarse-grained molecular simulations
por: Shillcock, Julian C., et al.
Publicado: (2021)

Fluorescence Microscopy: a statistics-optics perspective
por: Fazel, Mohamadreza, et al.
Publicado: (2023)

Spectral cross-cumulants for multicolor super-resolved SOFI imaging
por: Grußmayer, K. S., et al.
Publicado: (2020)

Complementarity of PALM and SOFI for super-resolution live-cell imaging of focal adhesions
por: Deschout, Hendrik, et al.
Publicado: (2016)

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
por: Riguet, Nathan, et al.
Publicado: (2021)

Deep Learning in Label-free Cell Classification
por: Chen, Claire Lifan, et al.
Publicado: (2016)

Revealing architectural order with quantitative label-free imaging and deep learning
por: Guo, Syuan-Ming, et al.
Publicado: (2020)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
por: Ellmer, Doris, et al.
Publicado: (2019)

Correlative 3D microscopy of single cells using super-resolution and scanning ion-conductance microscopy
por: Navikas, Vytautas, et al.
Publicado: (2021)

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
por: Limorenko, Galina, et al.
Publicado: (2023)

What about faculty?
por: Lashuel, Hilal A
Publicado: (2020)

Remembering John Q Trojanowski, in his own words: A life dedicated to discovering building blocks and using them to build bridges of knowledge, collaboration, and discovery
por: Lashuel, Hilal A.
Publicado: (2022)

Bio-orthogonal Red and Far-Red Fluorogenic Probes for Wash-Free Live-Cell and Super-resolution Microscopy
por: Werther, Philipp, et al.
Publicado: (2021)

Semiotic Aggregation in Deep Learning
por: Muşat, Bogdan, et al.
Publicado: (2020)

Label‐Free Identification of White Blood Cells Using Machine Learning
por: Nassar, Mariam, et al.
Publicado: (2019)

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
por: Kumar, Senthil T., et al.
Publicado: (2023)

Label‐free quality control and identification of human keratinocyte stem cells by deep learning‐based automated cell tracking
por: Hirose, Takuya, et al.
Publicado: (2021)

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
por: DeGuire, Sean M., et al.
Publicado: (2018)

Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification
por: Liu, Rongrong, et al.
Publicado: (2019)

Rapid and precise detection of cancers via label-free SERS and deep learning
por: Xiong, Chang-Chun, et al.
Publicado: (2023)

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies
por: Magalhães, Pedro, et al.
Publicado: (2022)

Identification of piRNA disease associations using deep learning
por: Ali, Syed Danish, et al.
Publicado: (2022)

A Versatile Deep Learning Architecture for Classification and Label-Free Prediction of Hyperspectral Images
por: Manifold, Bryce, et al.
Publicado: (2021)

Automatic deep learning-driven label-free image-guided patch clamp system
por: Koos, Krisztian, et al.
Publicado: (2021)

Label-free tumor cells classification using deep learning and high-content imaging
por: Piansaddhayanon, Chawan, et al.
Publicado: (2023)

Label-Free Capacitance-Based Identification of Viruses
por: Ahmad, Mahmoud Al, et al.
Publicado: (2015)

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation
por: Chiki, Anass, et al.
Publicado: (2021)

Rapid, label-free histopathological diagnosis of liver cancer based on Raman spectroscopy and deep learning
por: Huang, Liping, et al.
Publicado: (2023)

Deep learning-based label-free hematology analysis framework using optical diffraction tomography
por: Ryu, Dongmin, et al.
Publicado: (2023)

Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue using Deep Learning
por: Bai, Bijie, et al.
Publicado: (2022)

Label-Free White Blood Cell Classification Using Refractive Index Tomography and Deep Learning
por: Ryu, DongHun, et al.
Publicado: (2021)

Label-free deep learning-based species classification of bacteria imaged by phase-contrast microscopy
por: Hallström, Erik, et al.
Publicado: (2023)

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils
por: Ruggeri, Francesco Simone, et al.
Publicado: (2018)

Deep and fast label-free Dynamic Organellar Mapping
por: Schessner, Julia P., et al.
Publicado: (2023)

PhaseStain: the digital staining of label-free quantitative phase microscopy images using deep learning
por: Rivenson, Yair, et al.
Publicado: (2019)

Deep-Learning Based Label-Free Classification of Activated and Inactivated Neutrophils for Rapid Immune State Monitoring
por: Huang, Xiwei, et al.
Publicado: (2021)

Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells
por: Lee, Moosung, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0kktbskd4bmnq8hdo2oesjrbm4