Unexpected dynamics in femtomolar complexes of binding proteins with peptides

Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from the Armadillo repeat proteins (ArmRPs) can be designed to interact very tightly with fully flexible peptides. Here we show for ArmRPs with four...

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Detalles Bibliográficos
Autores principales: Cucuzza, Stefano, Sitnik, Malgorzata, Jurt, Simon, Michel, Erich, Dai, Wenzhao, Müntener, Thomas, Ernst, Patrick, Häussinger, Daniel, Plückthun, Andreas, Zerbe, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684580/
https://www.ncbi.nlm.nih.gov/pubmed/38016954
http://dx.doi.org/10.1038/s41467-023-43596-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684580/
https://www.ncbi.nlm.nih.gov/pubmed/38016954
http://dx.doi.org/10.1038/s41467-023-43596-2

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