High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints

Isavuconazole exposure–response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%. We observed a median (range) unbound fraction of 1.59% (0.42–5.30%) in patients. This highly variable protein binding asks for re-evaluation...

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Detalles Bibliográficos
Autores principales: Jansen, Anouk M. E., ter Heine, Rob, Verweij, Paul E., Brüggemann, Roger J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684614/
https://www.ncbi.nlm.nih.gov/pubmed/37819504
http://dx.doi.org/10.1007/s40262-023-01311-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684614/
https://www.ncbi.nlm.nih.gov/pubmed/37819504
http://dx.doi.org/10.1007/s40262-023-01311-w

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