Inhibition of rat locus coeruleus neurons by prostaglandin E(2) EP3 receptors: pharmacological characterization ex vivo

Prostaglandin E(2) (PGE(2)) is an inflammatory mediator synthesized by the brain constitutive cyclooxygenase enzyme. PGE(2) binds to G protein-coupled EP1-4 receptors (EP1 to G(q), EP2,4 to G(s), and EP3 to G(i/o)). EP2, EP3 and EP4 receptors are expressed in the locus coeruleus (LC), the main norad...

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Detalles Bibliográficos
Autores principales: Nazabal, Amaia, Mendiguren, Aitziber, Pineda, Joseba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684765/
https://www.ncbi.nlm.nih.gov/pubmed/38035000
http://dx.doi.org/10.3389/fphar.2023.1290605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684765/
https://www.ncbi.nlm.nih.gov/pubmed/38035000
http://dx.doi.org/10.3389/fphar.2023.1290605

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