Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity

Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain development in vitro. Typically, the fate of PSCs is guided into subsequent specification steps through static medium switches. In vivo, morphogen gradients are critical for proper brain development and determi...

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Detalles Bibliográficos
Autores principales: Pagliaro, Anna, Finger, Roxy, Zoutendijk, Iris, Bunschuh, Saskia, Clevers, Hans, Hendriks, Delilah, Artegiani, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684874/
https://www.ncbi.nlm.nih.gov/pubmed/38016960
http://dx.doi.org/10.1038/s41467-023-43141-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684874/
https://www.ncbi.nlm.nih.gov/pubmed/38016960
http://dx.doi.org/10.1038/s41467-023-43141-1

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