Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment

Wild-type reovirus serotype 3 Dearing (T3wt), a non-pathogenic intestinal virus, has shown promise as a cancer therapy in clinical trials, but it would benefit from an increased potency. Given that T3wt is naturally adapted to the intestinal environment (rather than tumors), we genetically modified...

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Detalles Bibliográficos
Autores principales: Cristi, Francisca, Walters, Maiah, Narayan, Nashae, Agopsowicz, Kate, Hitt, Mary M., Shmulevitz, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685048/
https://www.ncbi.nlm.nih.gov/pubmed/38033400
http://dx.doi.org/10.1016/j.omto.2023.100743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685048/
https://www.ncbi.nlm.nih.gov/pubmed/38033400
http://dx.doi.org/10.1016/j.omto.2023.100743

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