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Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment
Wild-type reovirus serotype 3 Dearing (T3wt), a non-pathogenic intestinal virus, has shown promise as a cancer therapy in clinical trials, but it would benefit from an increased potency. Given that T3wt is naturally adapted to the intestinal environment (rather than tumors), we genetically modified...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685048/ https://www.ncbi.nlm.nih.gov/pubmed/38033400 http://dx.doi.org/10.1016/j.omto.2023.100743 |