Uncoupling cytosolic calcium from membrane voltage by transient receptor potential melastatin 4 channel (TRPM4) modulation: A novel strategy to treat ventricular arrhythmias

The current antiarrhythmic paradigm is mainly centered around modulating membrane voltage. However, abnormal cytosolic calcium (Ca(2+)) signaling, which plays an important role in driving membrane voltage, has not been targeted for therapeutic purposes in arrhythmogenesis. There is clear evidence fo...

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Detalles Bibliográficos
Autores principales: Chakraborty, Praloy, Azam, Mohammed Ali, Massé, Stéphane, Lai, Patrick F.H., Rose, Robert A., Ibarra Moreno, Carlos A., Riazi, Sheila, Nanthakumar, Kumaraswamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Topics in Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685170/
https://www.ncbi.nlm.nih.gov/pubmed/38034891
http://dx.doi.org/10.1016/j.hroo.2023.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685170/
https://www.ncbi.nlm.nih.gov/pubmed/38034891
http://dx.doi.org/10.1016/j.hroo.2023.10.001

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