Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones

[Image: see text] Based on an amino-group-assisted coordination strategy and a proton-shuttle-activated outer-sphere mode, the cobalt-catalyzed asymmetric hydrogenation of α-primary amino ketones has been developed, resulting in the efficient synthesis of chiral vicinal amino alcohols bearing functi...

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Autores principales: Yang, Huiwen, Hu, Yanhua, Zou, Yashi, Zhang, Zhenfeng, Zhang, Wanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685343/
https://www.ncbi.nlm.nih.gov/pubmed/38034968
http://dx.doi.org/10.1021/jacsau.3c00524
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author Yang, Huiwen
Hu, Yanhua
Zou, Yashi
Zhang, Zhenfeng
Zhang, Wanbin
author_facet Yang, Huiwen
Hu, Yanhua
Zou, Yashi
Zhang, Zhenfeng
Zhang, Wanbin
author_sort Yang, Huiwen
collection PubMed
description [Image: see text] Based on an amino-group-assisted coordination strategy and a proton-shuttle-activated outer-sphere mode, the cobalt-catalyzed asymmetric hydrogenation of α-primary amino ketones has been developed, resulting in the efficient synthesis of chiral vicinal amino alcohols bearing functionalized aryl rings in high yields and enantioselectivities (up to 99% enantiomeric excess (ee)) within 0.5 h.
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spelling pubmed-106853432023-11-30 Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones Yang, Huiwen Hu, Yanhua Zou, Yashi Zhang, Zhenfeng Zhang, Wanbin JACS Au [Image: see text] Based on an amino-group-assisted coordination strategy and a proton-shuttle-activated outer-sphere mode, the cobalt-catalyzed asymmetric hydrogenation of α-primary amino ketones has been developed, resulting in the efficient synthesis of chiral vicinal amino alcohols bearing functionalized aryl rings in high yields and enantioselectivities (up to 99% enantiomeric excess (ee)) within 0.5 h. American Chemical Society 2023-10-20 /pmc/articles/PMC10685343/ /pubmed/38034968 http://dx.doi.org/10.1021/jacsau.3c00524 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yang, Huiwen
Hu, Yanhua
Zou, Yashi
Zhang, Zhenfeng
Zhang, Wanbin
Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title_full Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title_fullStr Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title_full_unstemmed Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title_short Cobalt-Catalyzed Efficient Asymmetric Hydrogenation of α-Primary Amino Ketones
title_sort cobalt-catalyzed efficient asymmetric hydrogenation of α-primary amino ketones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685343/
https://www.ncbi.nlm.nih.gov/pubmed/38034968
http://dx.doi.org/10.1021/jacsau.3c00524
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AT zouyashi cobaltcatalyzedefficientasymmetrichydrogenationofaprimaryaminoketones
AT zhangzhenfeng cobaltcatalyzedefficientasymmetrichydrogenationofaprimaryaminoketones
AT zhangwanbin cobaltcatalyzedefficientasymmetrichydrogenationofaprimaryaminoketones

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