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Characterization on the oncogenic effect of the missense mutations of p53 via machine learning

Dysfunctions caused by missense mutations in the tumour suppressor p53 have been extensively shown to be a leading driver of many cancers. Unfortunately, it is time-consuming and labour-intensive to experimentally elucidate the effects of all possible missense variants. Recent works presented a comp...

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Detalles Bibliográficos
Autores principales: Pan, Qisheng, Portelli, Stephanie, Nguyen, Thanh Binh, Ascher, David B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685404/
https://www.ncbi.nlm.nih.gov/pubmed/38018912
http://dx.doi.org/10.1093/bib/bbad428