Short, Scalable Access to Pyrrovobasine

[Image: see text] A concise gram-scale synthesis of pyrrovobasine (1) is reported. Key transformations include a three-step decagram-scale synthesis of the tetracyclic compound, Mn-mediated direct radical cyclization, and the introduction of a naturally rare pyrraline structure. The synthesis is des...

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Detalles Bibliográficos
Autores principales: Yu, Longhui, Nakamura, Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685420/
https://www.ncbi.nlm.nih.gov/pubmed/38034961
http://dx.doi.org/10.1021/jacsau.3c00595
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author Yu, Longhui
Nakamura, Hugh
author_facet Yu, Longhui
Nakamura, Hugh
author_sort Yu, Longhui
collection PubMed
description [Image: see text] A concise gram-scale synthesis of pyrrovobasine (1) is reported. Key transformations include a three-step decagram-scale synthesis of the tetracyclic compound, Mn-mediated direct radical cyclization, and the introduction of a naturally rare pyrraline structure. The synthesis is designed to be applicable to gram-scale synthesis using inexpensive and readily available reagents.
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spelling pubmed-106854202023-11-30 Short, Scalable Access to Pyrrovobasine Yu, Longhui Nakamura, Hugh JACS Au [Image: see text] A concise gram-scale synthesis of pyrrovobasine (1) is reported. Key transformations include a three-step decagram-scale synthesis of the tetracyclic compound, Mn-mediated direct radical cyclization, and the introduction of a naturally rare pyrraline structure. The synthesis is designed to be applicable to gram-scale synthesis using inexpensive and readily available reagents. American Chemical Society 2023-11-09 /pmc/articles/PMC10685420/ /pubmed/38034961 http://dx.doi.org/10.1021/jacsau.3c00595 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Yu, Longhui
Nakamura, Hugh
Short, Scalable Access to Pyrrovobasine
title Short, Scalable Access to Pyrrovobasine
title_full Short, Scalable Access to Pyrrovobasine
title_fullStr Short, Scalable Access to Pyrrovobasine
title_full_unstemmed Short, Scalable Access to Pyrrovobasine
title_short Short, Scalable Access to Pyrrovobasine
title_sort short, scalable access to pyrrovobasine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685420/
https://www.ncbi.nlm.nih.gov/pubmed/38034961
http://dx.doi.org/10.1021/jacsau.3c00595
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