Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression

PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not expressed in normal prostate tissue cells. The specific expression of prostate-specific antigen (PSA) is found to be related with the conditional transcriptional regulation of it...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Mei, Hongbing, Han, Xiaohong, Zhang, Xintao, Cheng, Jianli, Zhang, Zhongfu, Wang, Han, Xu, Haixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685504/
https://www.ncbi.nlm.nih.gov/pubmed/38017385
http://dx.doi.org/10.1186/s11658-023-00508-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685504/
https://www.ncbi.nlm.nih.gov/pubmed/38017385
http://dx.doi.org/10.1186/s11658-023-00508-y

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