Cargando…

Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression

PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not expressed in normal prostate tissue cells. The specific expression of prostate-specific antigen (PSA) is found to be related with the conditional transcriptional regulation of it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yi, Mei, Hongbing, Han, Xiaohong, Zhang, Xintao, Cheng, Jianli, Zhang, Zhongfu, Wang, Han, Xu, Haixia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685504/ https://www.ncbi.nlm.nih.gov/pubmed/38017385 http://dx.doi.org/10.1186/s11658-023-00508-y

Ejemplares similares

Downregulation of CacyBP by CRISPR/dCas9-KRAB Prevents Bladder Cancer Progression
por: Zheng, Hanxiong, et al.
Publicado: (2021)

Transcriptional Inhibition of lncRNA gadd7 by CRISPR/dCas9-KRAB Protects Spermatocyte Viability
por: Zhao, Jun, et al.
Publicado: (2021)

Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
por: da Costa, Lendel Correia, et al.
Publicado: (2022)

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner
por: O’Geen, Henriette, et al.
Publicado: (2019)

CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma Cells
por: Roy Choudhury, Samrat, et al.
Publicado: (2023)

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
por: O’Geen, Henriette, et al.
Publicado: (2022)

Temperature Control of psaA Expression by PsaE and PsaF in Yersinia pestis
por: Quinn, Joshua D., et al.
Publicado: (2019)

Urinary PSA and Serum PSA for Aggressive Prostate Cancer Detection
por: Höti, Naseruddin, et al.
Publicado: (2023)

Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons
por: Li, Aiqun, et al.
Publicado: (2021)

Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors
por: Wang, Hong, et al.
Publicado: (2018)

The Relationship between Prostate Biopsy Results and PSA and Free PSA Ratio Changes in Elevated Serum PSA Patients with and without Antibiotherapy
por: Duran, Mesut Berkan, et al.
Publicado: (2020)

Prognostic significance of a novel indicator (PSA(postd3)/PSA(pre)) for PSA recurrence in patients after radical prostatectomy
por: Zhou, Zhien, et al.
Publicado: (2019)

Zonal adjusted PSA density improves prostate cancer detection rates compared with PSA in Taiwanese males with PSA < 20 ng/ml
por: Chang, Tsung-Hsin, et al.
Publicado: (2020)

CRISPR/dCas9-mediated biosensor for detection of tick-borne diseases
por: Koo, Bonhan, et al.
Publicado: (2018)

Establishment of reference intervals for serum [−2]proPSA (p2PSA), %p2PSA and prostate health index in healthy men
por: Wu, Zhi-Yu, et al.
Publicado: (2019)

Detection of prostate cancer with complexed PSA and complexed/total PSA ratio - is there any advantage?
por: Strittmatter, F, et al.
Publicado: (2011)

A Comparative Performance Analysis of Total PSA, Percentage Free PSA, PSA Velocity, and PSA Density versus the Detection of Primary Circulating Prostate Cells in Predicting Initial Prostate Biopsy Findings in Chilean Men
por: Murray, Nigel P., et al.
Publicado: (2014)

Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation
por: Shao, Jiawei, et al.
Publicado: (2018)

PSA screening – for whom and when?
por: Albers, Peter
Publicado: (2019)

Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA.
por: Nilsson, O., et al.
Publicado: (1997)

Nadir PSA level and time to nadir PSA are prognostic factors in patients with metastatic prostate cancer
por: Tomioka, Atsushi, et al.
Publicado: (2014)

Time to PSA rise differentiates the PSA bounce after HDR and LDR brachytherapy of prostate cancer
por: Burchardt, Wojciech, et al.
Publicado: (2018)

Assessment of the many faces of PsA: single and composite measures in PsA clinical trials
por: McGagh, Dylan, et al.
Publicado: (2020)

Detection of CRISPR-dCas9 on DNA with Solid-State Nanopores
por: Yang, Wayne, et al.
Publicado: (2018)

PSA 1972 : proceedings of the 1972 biennial meeting philosophy of science association
Publicado: (1974)

Association of Polymorphisms in the Prostate-Specific Antigen (PSA) Gene Promoter with Serum PSA Level and PSA Changes after Dutasteride Treatment in Korean Men with Benign Prostatic Hypertrophy
por: Park, Sung Woon, et al.
Publicado: (2010)

Free PSA performs better than total PSA in predicting prostate volume in Chinese men with PSA levels of 2.5–9.9 ng ml(−1)
por: Huang, Ma-Ping, et al.
Publicado: (2022)

Association of serum prostate-specific antigen (PSA) level and circulating tumor cell-based PSA mRNA in prostate cancer
por: Cho, Hyungseok, et al.
Publicado: (2022)

Exploration of the Value of Combined UA, IL-6, and fPSA/tPSA in the Diagnosis of Prostate Cancer
por: Tang, Qionghua, et al.
Publicado: (2022)

CRISPR/dCas9-Mediated Gene Silencing in Two Plant Fungal Pathogens
por: Zhang, Yun-mu, et al.
Publicado: (2023)

Clinical Use of [-2]proPSA (p2PSA) and Its Derivatives (%p2PSA and Prostate Health Index) for the Detection of Prostate Cancer: A Review of the Literature
por: Abrate, Alberto, et al.
Publicado: (2014)

CRISPR-Cas13-Mediated Knockdown of lncRNA-GACAT3 Inhibited Cell Proliferation and Motility, and Induced Apoptosis by Increasing p21, Bax, and E-Cadherin Expression in Bladder Cancer
por: Zhang, Zhongfu, et al.
Publicado: (2021)

Theory of stellar pulsation (PSA-2)
por: Cox, John P
Publicado: (2017)

Multiparametric MRI in the PSA Screening Era
por: George, Arvin K., et al.
Publicado: (2014)

Fasting times in serum PSA assay
por: Xu, Xiang, et al.
Publicado: (2014)

PSA mass screening: is there enough evidence?
por: Rocco, Bernardo, et al.
Publicado: (2012)

Rheological and Mechanical Properties of an Acrylic PSA
por: Simões, Beatriz D., et al.
Publicado: (2023)

Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice
por: Duan, Jinzhi, et al.
Publicado: (2018)

Activating PTEN Tumor Suppressor Expression with the CRISPR/dCas9 System
por: Moses, Colette, et al.
Publicado: (2018)

Digital logic circuits in yeast with CRISPR-dCas9 NOR gates
por: Gander, Miles W., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b14h2evjf48og8h5ggrbb7prtg