Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery

Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are essential for the TNFα- and IL-1-mediated NF-κB signaling pathways. However, recent studies have discover...

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Detalles Bibliográficos
Autores principales: Li, Jack, Liu, Sijin, Li, Shitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685518/
https://www.ncbi.nlm.nih.gov/pubmed/38017534
http://dx.doi.org/10.1186/s12964-023-01239-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685518/
https://www.ncbi.nlm.nih.gov/pubmed/38017534
http://dx.doi.org/10.1186/s12964-023-01239-5

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