Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach

BACKGROUND: Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require life-long treatment due to leukaemic stem cell (LSC) persistence. LSCs reside in the bone marrow (BM) niche, which they modify to their advantage. The BM provides on...

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Detalles Bibliográficos
Autores principales: Busch, Caroline, Mulholland, Theresa, Zagnoni, Michele, Dalby, Matthew, Berry, Catherine, Wheadon, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685629/
https://www.ncbi.nlm.nih.gov/pubmed/38031192
http://dx.doi.org/10.1186/s12964-023-01363-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685629/
https://www.ncbi.nlm.nih.gov/pubmed/38031192
http://dx.doi.org/10.1186/s12964-023-01363-2

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