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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system

Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes. Seven intact Alox genes have been detected in the mouse reference genome and the mouse Alox15 gene is structurally similar to the orthologous genes of othe...

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Detalles Bibliográficos
Autores principales: Reisch, Florian, Heydeck, Dagmar, Schäfer, Marjann, Rothe, Michael, Yang, Jiaxing, Stehling, Sabine, Püschel, Gerhard P., Kuhn, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685687/
https://www.ncbi.nlm.nih.gov/pubmed/38030974
http://dx.doi.org/10.1186/s11658-023-00511-3