Covalent targeting of non-cysteine residues in PI4KIIIβ

The synthesis and characterisation of fluorosulfate covalent inhibitors of the lipid kinase PI4KIIIβ is described. The conserved lysine residue located within the ATP binding site was targeted, and optimised compounds based upon reversible inhibitors with good activity and physicochemical profile sh...

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Detalles Bibliográficos
Autores principales: Cosgrove, Brett, Grant, Emma K., Bertrand, Sophie, Down, Kenneth D., Somers, Don O., P. Evans, John, Tomkinson, Nicholas C. O., Barker, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685791/
https://www.ncbi.nlm.nih.gov/pubmed/38033723
http://dx.doi.org/10.1039/d3cb00142c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685791/
https://www.ncbi.nlm.nih.gov/pubmed/38033723
http://dx.doi.org/10.1039/d3cb00142c

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