Biotransformation-coupled mutasynthesis for the generation of novel pristinamycin derivatives by engineering the phenylglycine residue

Streptogramins are the last line of defense antimicrobials with pristinamycin as a representative substance used as therapeutics against highly resistant pathogenic bacteria. However, the emergence of (multi)drug-resistant pathogens renders these valuable antibiotics useless; making it necessary to...

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Detalles Bibliográficos
Autores principales: Hennrich, Oliver, Weinmann, Leoni, Kulik, Andreas, Harms, Karen, Klahn, Philipp, Youn, Jung-Won, Surup, Frank, Mast, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685826/
https://www.ncbi.nlm.nih.gov/pubmed/38033732
http://dx.doi.org/10.1039/d3cb00143a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685826/
https://www.ncbi.nlm.nih.gov/pubmed/38033732
http://dx.doi.org/10.1039/d3cb00143a

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