MDSCs-derived GPR84 induces CD8(+) T-cell senescence via p53 activation to suppress the antitumor response

BACKGROUNDS: G-protein-coupled receptor 84 (GPR84) marks a subset of myeloid-derived suppressor cells (MDSCs) with stronger immunosuppression in the tumor microenvironment. Yet, how GPR84 endowed the stronger inhibition of MDSCs to CD8(+) T cells function is not well established. In this study, we a...

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Detalles Bibliográficos
Autores principales: Liu, Jinyan, Liu, Jiayin, Qin, Guohui, Li, Jiahui, Fu, Ziyi, Li, Jieyao, Li, Miaomiao, Guo, Caijuan, Zhao, Ming, Zhang, Zhen, Li, Feng, Zhao, Xuan, Wang, Liping, Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685939/
https://www.ncbi.nlm.nih.gov/pubmed/38016719
http://dx.doi.org/10.1136/jitc-2023-007802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10685939/
https://www.ncbi.nlm.nih.gov/pubmed/38016719
http://dx.doi.org/10.1136/jitc-2023-007802

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