Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

Site-directed Enzyme Enhancement Therapy (SEE-Tx®) technology is a disease-agnostic drug discovery tool that can be applied to any protein target of interest with a known three-dimensional structure. We used this proprietary technology to identify and characterize the therapeutic potential of struct...

Descripción completa

Detalles Bibliográficos
Autores principales: Rudinskiy, Mikhail, Pons-Vizcarra, Maria, Soldà, Tatiana, Fregno, Ilaria, Bergmann, Timothy Jan, Ruano, Ana, Delgado, Aida, Morales, Sara, Barril, Xavier, Bellotto, Manolo, Cubero, Elena, García-Collazo, Ana María, Pérez-Carmona, Natalia, Molinari, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686464/
https://www.ncbi.nlm.nih.gov/pubmed/38019733
http://dx.doi.org/10.1371/journal.pone.0294437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686464/
https://www.ncbi.nlm.nih.gov/pubmed/38019733
http://dx.doi.org/10.1371/journal.pone.0294437

Ejemplares similares