Cas9 is mostly orthogonal to human systems of DNA break sensing and repair

CRISPR/Cas9 system is а powerful gene editing tool based on the RNA-guided cleavage of target DNA. The Cas9 activity can be modulated by proteins involved in DNA damage signalling and repair due to their interaction with double- and single-strand breaks (DSB and SSB, respectively) generated by wild-...

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Detalles Bibliográficos
Autores principales: Maltseva, Ekaterina A., Vasil’eva, Inna A., Moor, Nina A., Kim, Daria V., Dyrkheeva, Nadezhda S., Kutuzov, Mikhail M., Vokhtantsev, Ivan P., Kulishova, Lilya M., Zharkov, Dmitry O., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686484/
https://www.ncbi.nlm.nih.gov/pubmed/38019812
http://dx.doi.org/10.1371/journal.pone.0294683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686484/
https://www.ncbi.nlm.nih.gov/pubmed/38019812
http://dx.doi.org/10.1371/journal.pone.0294683

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