Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity

Cancer immunotherapy is moving toward combination regimens with agents of complementary mechanisms of action to achieve more frequent and robust efficacy. However, compared with single-agent therapies, combination immunotherapies are associated with increased overall toxicity because the very same m...

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Detalles Bibliográficos
Autores principales: Kang, Seounghun, Mansurov, Aslan, Kurtanich, Trevin, Chun, Hye Rin, Slezak, Anna J., Volpatti, Lisa R., Chang, Kevin, Wang, Thomas, Alpar, Aaron T., Refvik, Kirsten C., Hansen, O. Isabella, Borjas, Gustavo J., Shim, Ha-Na, Hultgren, Kevin T., Gomes, Suzana, Solanki, Ani, Ishihara, Jun, Swartz, Melody A., Hubbell, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686557/
https://www.ncbi.nlm.nih.gov/pubmed/38019919
http://dx.doi.org/10.1126/sciadv.adh9879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686557/
https://www.ncbi.nlm.nih.gov/pubmed/38019919
http://dx.doi.org/10.1126/sciadv.adh9879

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