Lower cardiotoxicity of CPX-351 relative to daunorubicin plus cytarabine free-drug combination in hiPSC-derived cardiomyocytes in vitro

Liposomal formulations are hypothesized to alleviate anthracycline cardiotoxicity, although this has only been documented clinically for doxorubicin. We developed an in vitro multiparametric model using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to assess the relative toxi...

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Detalles Bibliográficos
Autores principales: Fortin, Marie C., LaCroix, Andrew S., Grammatopoulos, Tom N., Tan, Lei, Wang, Qi, Manca, Dino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686991/
https://www.ncbi.nlm.nih.gov/pubmed/38030645
http://dx.doi.org/10.1038/s41598-023-47293-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686991/
https://www.ncbi.nlm.nih.gov/pubmed/38030645
http://dx.doi.org/10.1038/s41598-023-47293-4

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