Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate im...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Ming-Ming, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687031/
https://www.ncbi.nlm.nih.gov/pubmed/37932533
http://dx.doi.org/10.1038/s41423-023-01086-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687031/
https://www.ncbi.nlm.nih.gov/pubmed/37932533
http://dx.doi.org/10.1038/s41423-023-01086-x

Ejemplares similares