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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING pathway, resulting in the induced expression of type I interferon and other effector genes. These processes contribute to the innate im...

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Detalles Bibliográficos
Autores principales:	Hu, Ming-Ming, Shu, Hong-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687031/ https://www.ncbi.nlm.nih.gov/pubmed/37932533 http://dx.doi.org/10.1038/s41423-023-01086-x

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