PD-1(-) CD45RA(+) effector-memory CD8 T cells and CXCL10(+) macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma

The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-tumoural and peripheral immune context of patients with aHC...

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Detalles Bibliográficos
Autores principales: Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687033/
https://www.ncbi.nlm.nih.gov/pubmed/38030622
http://dx.doi.org/10.1038/s41467-023-43381-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687033/
https://www.ncbi.nlm.nih.gov/pubmed/38030622
http://dx.doi.org/10.1038/s41467-023-43381-1

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