“Boundary residues” between the folded RNA recognition motif and disordered RGG domains are critical for FUS–RNA binding

Fused in sarcoma (FUS) is an abundant RNA-binding protein, which drives phase separation of cellular condensates and plays multiple roles in RNA regulation. The RNA-binding ability of FUS protein is crucial to its cellular function. Here, our molecular simulation study on the FUS–RNA complex provide...

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Detalles Bibliográficos
Autores principales: Balasubramanian, Sangeetha, Maharana, Shovamayee, Srivastava, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687056/
https://www.ncbi.nlm.nih.gov/pubmed/37890778
http://dx.doi.org/10.1016/j.jbc.2023.105392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687056/
https://www.ncbi.nlm.nih.gov/pubmed/37890778
http://dx.doi.org/10.1016/j.jbc.2023.105392

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