Molecular mechanism of EAG1 channel inhibition by imipramine binding to the PAS domain

Ether-a-go-go (EAG) channels are key regulators of neuronal excitability and tumorigenesis. EAG channels contain an N-terminal Per-Arnt-Sim (PAS) domain that can regulate currents from EAG channels by binding small molecules. The molecular mechanism of this regulation is not clear. Using surface pla...

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Detalles Bibliográficos
Autores principales: Wang, Ze-Jun, Ghorbani, Mahdi, Chen, Xi, Tiwari, Purushottam B., Klauda, Jeffery B., Brelidze, Tinatin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687071/
https://www.ncbi.nlm.nih.gov/pubmed/37898402
http://dx.doi.org/10.1016/j.jbc.2023.105391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687071/
https://www.ncbi.nlm.nih.gov/pubmed/37898402
http://dx.doi.org/10.1016/j.jbc.2023.105391

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