Cargando…

Molecular mechanism of EAG1 channel inhibition by imipramine binding to the PAS domain

Ether-a-go-go (EAG) channels are key regulators of neuronal excitability and tumorigenesis. EAG channels contain an N-terminal Per-Arnt-Sim (PAS) domain that can regulate currents from EAG channels by binding small molecules. The molecular mechanism of this regulation is not clear. Using surface pla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ze-Jun, Ghorbani, Mahdi, Chen, Xi, Tiwari, Purushottam B., Klauda, Jeffery B., Brelidze, Tinatin I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687071/ https://www.ncbi.nlm.nih.gov/pubmed/37898402 http://dx.doi.org/10.1016/j.jbc.2023.105391

Ejemplares similares

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels
por: Wang, Ze-Jun, et al.
Publicado: (2019)

Flavonoid regulation of EAG1 channels
por: Carlson, Anne E., et al.
Publicado: (2013)

Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance
por: Soohoo, Stephanie M., et al.
Publicado: (2021)

Crystal structure of the PAS domain of the hEAG potassium channel
por: Tang, Xue, et al.
Publicado: (2016)

Mechanism of Block of hEag1 K(+) Channels by Imipramine and Astemizole
por: García-Ferreiro, Rafael E., et al.
Publicado: (2004)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Identifying Regulators for EAG1 Channels with a Novel Electrophysiology and Tryptophan Fluorescence Based Screen
por: Brelidze, Tinatin I., et al.
Publicado: (2010)

The Eag Domain Regulates the Voltage-Dependent Inactivation of Rat Eag1 K(+) Channels
por: Lin, Ting-Feng, et al.
Publicado: (2014)

The structural mechanism of KCNH-channel regulation by the eag domain
por: Haitin, Yoni, et al.
Publicado: (2013)

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain
por: Lörinczi, Eva, et al.
Publicado: (2016)

N- and C-terminal interactions in KCNH channels: The spotlight on the intrinsic ligand
por: Brelidze, Tinatin I.
Publicado: (2019)

Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
por: Codding, Sara J., et al.
Publicado: (2020)

Direct interaction of eag domains and cyclic nucleotide–binding homology domains regulate deactivation gating in hERG channels
por: Gianulis, Elena C., et al.
Publicado: (2013)

Heteromeric wild-type/mutant potassium channel subunit composition as a major determinant of channelopathy phenotype in heterozygous patients
por: Brelidze, Tinatin I.
Publicado: (2023)

Exploring dynamics and network analysis of spike glycoprotein of SARS-COV-2
por: Ghorbani, Mahdi, et al.
Publicado: (2021)

An Integrative MD Simulation and Network Analysis Approach to Study Glycosylation of Spike in SARS-CoV-2
por: Ghorbani, Mahdi, et al.
Publicado: (2021)

Probing the Geometry of the Inner Vestibule of BK Channels with Sugars
por: Brelidze, Tinatin I., et al.
Publicado: (2005)

Eag1 Channels as Potential Cancer Biomarkers
por: Rodríguez-Rasgado, Jesús Adrián, et al.
Publicado: (2012)

Protons Block BK Channels by Competitive Inhibition with K(+) and Contribute to the Limits of Unitary Currents at High Voltages
por: Brelidze, Tinatin I., et al.
Publicado: (2004)

Tuning of EAG K(+) channel inactivation: Molecular determinants of amplification by mutations and a small molecule
por: Garg, Vivek, et al.
Publicado: (2012)

Overexpression of Eag1 potassium channels in clinical tumours
por: Hemmerlein, Bernhard, et al.
Publicado: (2006)

The eag domain regulates hERG channel inactivation gating via a direct interaction
por: Gustina, Ahleah S., et al.
Publicado: (2013)

Regulation of Eag1 gating by its intracellular domains
por: Whicher, Jonathan R, et al.
Publicado: (2019)

External pH modulates EAG superfamily K(+) channels through EAG-specific acidic residues in the voltage sensor
por: Kazmierczak, Marcin, et al.
Publicado: (2013)

14-3-3θ is a Binding Partner of Rat Eag1 Potassium Channels
por: Hsu, Po-Hao, et al.
Publicado: (2012)

Dynamics of the EAG1 K(+) channel selectivity filter assessed by molecular dynamics simulations
por: Bernsteiner, Harald, et al.
Publicado: (2017)

Eag and HERG potassium channels as novel therapeutic targets in cancer
por: Asher, Viren, et al.
Publicado: (2010)

The mechanism study of Eag1 potassium channel in gastric cancer
por: Gao, Shan, et al.
Publicado: (2022)

A replica exchange umbrella sampling (REUS) approach to predict host–guest binding free energies in SAMPL8 challenge
por: Ghorbani, Mahdi, et al.
Publicado: (2021)

Regulation of hERG and hEAG Channels by Src and by SHP-1 Tyrosine Phosphatase via an ITIM Region in the Cyclic Nucleotide Binding Domain
por: Schlichter, Lyanne C., et al.
Publicado: (2014)

Structure of the C-terminal Region of a KCNH Channel
por: Brelidze, Tinatin I., et al.
Publicado: (2012)

Ca(2+)‐binding protein centrin 4 is a novel binding partner of rat Eag1 K(+) channels
por: Hsu, Po‐Hao, et al.
Publicado: (2016)

Structural Properties of PAS Domains from the KCNH Potassium Channels
por: Adaixo, Ricardo, et al.
Publicado: (2013)

Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth
por: Francisco, Michelle A., et al.
Publicado: (2020)

The Eag potassium channel as a new prognostic marker in ovarian cancer
por: Asher, Viren, et al.
Publicado: (2010)

Eag1 channels as potential early-stage biomarkers of hepatocellular carcinoma
por: Chávez-López, María de Guadalupe, et al.
Publicado: (2016)

Eag1 K(+) Channel: Endogenous Regulation and Functions in Nervous System
por: Han, Bo, et al.
Publicado: (2017)

Effects of calcium channel blockers on antidepressant action of Alprazolam and Imipramine
por: Aburawi, SM, et al.
Publicado: (2007)

Ring of Negative Charge in BK Channels Facilitates Block by Intracellular Mg(2+) and Polyamines through Electrostatics
por: Zhang, Yaxia, et al.
Publicado: (2006)

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
por: Liu, Qiang-ni, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h502mcb09lsht0bgsuqskmih7l