Non-canonical pathway for Rb inactivation and external signaling coordinate cell-cycle entry without CDK4/6 activity

Cyclin-dependent kinases 4 and 6 (CDK4/6) are critical for initiating cell proliferation by inactivating the retinoblastoma (Rb) protein. However, mammalian cells can bypass CDK4/6 for Rb inactivation. Here we show a non-canonical pathway for Rb inactivation and its interplay with external signals....

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Detalles Bibliográficos
Autores principales: Zhang, Mimi, Kim, Sungsoo, Yang, Hee Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687137/
https://www.ncbi.nlm.nih.gov/pubmed/38030655
http://dx.doi.org/10.1038/s41467-023-43716-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687137/
https://www.ncbi.nlm.nih.gov/pubmed/38030655
http://dx.doi.org/10.1038/s41467-023-43716-y

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