Arachidonate 15-lipoxygenase-mediated production of Resolvin D5(n-3 DPA) abrogates pancreatic stellate cell-induced cancer cell invasion

Activation of pancreatic stellate cells (PSCs) to cancer-associated fibroblasts (CAFs) is responsible for the extensive desmoplastic reaction observed in PDAC stroma: a key driver of pancreatic ductal adenocarcinoma (PDAC) chemoresistance leading to poor prognosis. Specialized pro-resolving mediator...

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Detalles Bibliográficos
Autores principales: Aguirre, Gabriel A., Goulart, Michelle R., Dalli, Jesmond, Kocher, Hemant M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687150/
https://www.ncbi.nlm.nih.gov/pubmed/38035115
http://dx.doi.org/10.3389/fimmu.2023.1248547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687150/
https://www.ncbi.nlm.nih.gov/pubmed/38035115
http://dx.doi.org/10.3389/fimmu.2023.1248547

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