A novel small molecule, CU05-1189, targeting the pleckstrin homology domain of PDK1 suppresses VEGF-mediated angiogenesis and tumor growth by blocking the Akt signaling pathway

Inhibition of angiogenesis is considered a promising therapeutic approach for cancer treatment. Our previous genetic research showed that the use of a cell-penetrating peptide to inhibit the pleckstrin homology (PH) domain of 3-phosphoinositide-dependent kinase 1 (PDK1) was a viable approach to supp...

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Detalles Bibliográficos
Autores principales: Park, Jeongeun, Zhang, Haiying, Kwak, Hyun Jung, Gadhe, Changdev Gorakshnath, Kim, Yeomyeong, Kim, Hyejeong, Noh, Minyoung, Shin, Dongyun, Ha, Sang-Jun, Kwon, Young-Guen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687218/
https://www.ncbi.nlm.nih.gov/pubmed/38035024
http://dx.doi.org/10.3389/fphar.2023.1275749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687218/
https://www.ncbi.nlm.nih.gov/pubmed/38035024
http://dx.doi.org/10.3389/fphar.2023.1275749

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