Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting

A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however, the mechanistic basis of these observations are unclear. Here we reveal two distinct mechanisms of Polθ synthetic lethal...

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Detalles Bibliográficos
Autores principales: Ronson, George E., Starowicz, Katarzyna, Anthony, Elizabeth J., Piberger, Ann Liza, Clarke, Lucy C., Garvin, Alexander J., Beggs, Andrew D., Whalley, Celina M., Edmonds, Matthew J., Beesley, James F. J., Morris, Joanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687250/
https://www.ncbi.nlm.nih.gov/pubmed/38030626
http://dx.doi.org/10.1038/s41467-023-43677-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687250/
https://www.ncbi.nlm.nih.gov/pubmed/38030626
http://dx.doi.org/10.1038/s41467-023-43677-2

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