1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors

We report a series of 1,3-diphenylureido hydroxamate HDAC inhibitors evaluated against sensitive and drug-resistant P. falciparum strains. Compounds 8a–d show potent antiplasmodial activity, indicating that a phenyl spacer allows improved potency relative to cinnamyl and di-hydrocinnamyl linkers. In...

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Detalles Bibliográficos
Autores principales: Tavares, Maurício T., Krüger, Arne, Yan, Sun L. Rei, Waitman, Karoline B., Gomes, Vinícius M., de Oliveira, Daffiny Sumam, Paz, Franciarli, Hilscher, Sebastian, Schutkowski, Mike, Sippl, Wolfgang, Ruiz, Claudia, Toledo, Mônica F. Z. J., Hassimotto, Neuza M. A., Machado-Neto, João A., Poso, Antti, Cameron, Michael D., Bannister, Thomas D., Palmisano, Giuseppe, Wrenger, Carsten, Kronenberger, Thales, Parise-Filho, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687260/
https://www.ncbi.nlm.nih.gov/pubmed/38030668
http://dx.doi.org/10.1038/s41598-023-47959-z

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