ZeroBind: a protein-specific zero-shot predictor with subgraph matching for drug-target interactions

Existing drug-target interaction (DTI) prediction methods generally fail to generalize well to novel (unseen) proteins and drugs. In this study, we propose a protein-specific meta-learning framework ZeroBind with subgraph matching for predicting protein-drug interactions from their structures. Durin...

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Detalles Bibliográficos
Autores principales: Wang, Yuxuan, Xia, Ying, Yan, Junchi, Yuan, Ye, Shen, Hong-Bin, Pan, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687269/
https://www.ncbi.nlm.nih.gov/pubmed/38030641
http://dx.doi.org/10.1038/s41467-023-43597-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687269/
https://www.ncbi.nlm.nih.gov/pubmed/38030641
http://dx.doi.org/10.1038/s41467-023-43597-1

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