Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1

cis-Diamminedichloroplatinum (CDDP) is widely used for the treatment of various solid cancers. Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2), along with the upregulation of pregnane X receptor (PXR) and the dow...

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Detalles Bibliográficos
Autores principales: Xu, Minqin, Zhang, Lihua, Lin, Lan, Qiang, Zhiyi, Liu, Wei, Yang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687532/
https://www.ncbi.nlm.nih.gov/pubmed/37990879
http://dx.doi.org/10.7555/JBR.37.20230047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687532/
https://www.ncbi.nlm.nih.gov/pubmed/37990879
http://dx.doi.org/10.7555/JBR.37.20230047

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