Cargando…

Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1

cis-Diamminedichloroplatinum (CDDP) is widely used for the treatment of various solid cancers. Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2), along with the upregulation of pregnane X receptor (PXR) and the dow...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Minqin, Zhang, Lihua, Lin, Lan, Qiang, Zhiyi, Liu, Wei, Yang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editorial Department of Journal of Biomedical Research 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687532/ https://www.ncbi.nlm.nih.gov/pubmed/37990879 http://dx.doi.org/10.7555/JBR.37.20230047

Ejemplares similares

Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes
por: Ning, Rui, et al.
Publicado: (2017)

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity
por: Jia, Yumeng, et al.
Publicado: (2022)

PXR as a mediator of herb–drug interaction
por: Hogle, Brett C., et al.
Publicado: (2017)

The roles of carboxylesterase and CYP isozymes on the in vitro metabolism of T-2 toxin
por: Lin, Ni-Ni, et al.
Publicado: (2015)

Human carboxylesterases: a comprehensive review
por: Wang, Dandan, et al.
Publicado: (2018)

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
por: Pavek, Petr
Publicado: (2016)

Arabidopsis Carboxylesterase 20 Binds Strigolactone and Increases Branches and Tillers When Ectopically Expressed in Arabidopsis and Maize
por: Roesler, Keith, et al.
Publicado: (2021)

The COVID‐19 Medicine Remdesivir Is Therapeutically Activated by Carboxylesterase‐1, and Excessive Hydrolysis Increases Cytotoxicity
por: Shen, Yue, et al.
Publicado: (2021)

DEC2 expression antagonizes cisplatin-induced apoptosis in human esophageal squamous cell carcinoma
por: Sato, Hidenobu, et al.
Publicado: (2017)

A Functional Polymorphism in the 3'-UTR of PXR Interacts with Smoking to Increase Lung Cancer Risk in Southern and Eastern Chinese Smoker
por: Zhang, Lisha, et al.
Publicado: (2014)

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile
por: Bailey, Ian, et al.
Publicado: (2011)

Zearalenone-Induced Interaction between PXR and Sp1 Increases Binding of Sp1 to a Promoter Site of the eNOS, Decreasing Its Transcription and NO Production in BAECs
por: Lee, Hyeon-Ju, et al.
Publicado: (2020)

Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity
por: Wang, Yu, et al.
Publicado: (2019)

PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice
por: Ye, Nanhui, et al.
Publicado: (2016)

Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma
por: Goeppert, Benjamin, et al.
Publicado: (2019)

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics
por: Di, Li
Publicado: (2018)

Small-molecule inhibitors of carboxylesterase Notum
por: Zhao, Yuguang, et al.
Publicado: (2021)

Salvia miltiorrhiza Bunge (Danshen) and Bioactive Compound Tanshinone IIA Alleviates Cisplatin-Induced Acute Kidney Injury Through Regulating PXR/NF-κB Signaling
por: Dou, Jing-Yun, et al.
Publicado: (2022)

Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease
por: Wilson, Aze, et al.
Publicado: (2020)

The role of pregnane X receptor (PXR) in substance metabolism
por: Lv, Ye, et al.
Publicado: (2022)

The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation
por: Wang, Xingzhi, et al.
Publicado: (2021)

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans
por: Oh, Jaeseong, et al.
Publicado: (2017)

ChIPing the cistrome of PXR in mouse liver
por: Cui, Julia Yue, et al.
Publicado: (2010)

Biology of PXR: role in drug-hormone interactions
por: Wang, Jing, et al.
Publicado: (2014)

PXR is a target of (-)-epicatechin in skeletal muscle
por: Ortiz-Flores, Miguel, et al.
Publicado: (2020)

Regulation of CAR and PXR Expression in Health and Disease
por: Daujat-Chavanieu, Martine, et al.
Publicado: (2020)

PXR: a center of transcriptional regulation in cancer
por: Xing, Yaqi, et al.
Publicado: (2020)

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
por: Karpale, Mikko, et al.
Publicado: (2022)

The Nuclear Receptor PXR in Chronic Liver Disease
por: Sayaf, Katia, et al.
Publicado: (2021)

PDCD5 transfection increases cisplatin sensitivity and decreases invasion in hepatic cancer cells
por: FAN, GUI-LING, et al.
Publicado: (2015)

Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression
por: Zou, Jiao, et al.
Publicado: (2018)

Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice
por: McMillan, JoEllyn M., et al.
Publicado: (2018)

Annotation and expression of carboxylesterases in the silkworm, Bombyx mori
por: Yu, Quan-You, et al.
Publicado: (2009)

Carboxylesterases in lipid metabolism: from mouse to human
por: Lian, Jihong, et al.
Publicado: (2017)

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids
por: Smutny, Tomas, et al.
Publicado: (2020)

Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
por: Caparrós-Martín, Jose A., et al.
Publicado: (2017)

Resveratrol ameliorates nutritional steatohepatitis through the mmu-miR-599/PXR pathway
por: Kong, Lingbo, et al.
Publicado: (2022)

Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis
por: Qin, Mengyao, et al.
Publicado: (2022)

DEC VT220
Publicado: (1983)

Milestone Dec. 85
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_67mm3rn9a101i3ns9dv7vsjgko