Cargando…

Improved production of Taxol(®) precursors in S. cerevisiae using combinatorial in silico design and metabolic engineering

BACKGROUND: Integrated metabolic engineering approaches that combine system and synthetic biology tools enable the efficient design of microbial cell factories for synthesizing high-value products. In this study, we utilized in silico design algorithms on the yeast genome-scale model to predict geno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Malcı, Koray, Santibáñez, Rodrigo, Jonguitud-Borrego, Nestor, Santoyo-Garcia, Jorge H., Kerkhoven, Eduard J., Rios-Solis, Leonardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687855/ https://www.ncbi.nlm.nih.gov/pubmed/38031061 http://dx.doi.org/10.1186/s12934-023-02251-7

Ejemplares similares

ACtivE: Assembly and CRISPR-Targeted in Vivo Editing for Yeast Genome Engineering Using Minimum Reagents and Time
por: Malcı, Koray, et al.
Publicado: (2022)

Enhanced production of taxadiene in Saccharomyces cerevisiae
por: Nowrouzi, Behnaz, et al.
Publicado: (2020)

High—throughput and automated screening for COVID-19
por: Jonguitud-Borrego, Nestor, et al.
Publicado: (2022)

Multiplex Genome Engineering Methods for Yeast Cell Factory Development
por: Malcı, Koray, et al.
Publicado: (2020)

Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae
por: Nowrouzi, Behnaz, et al.
Publicado: (2022)

Rational Design of CRISPR/Cas12a-RPA Based One-Pot COVID-19 Detection with Design of Experiments
por: Malcı, Koray, et al.
Publicado: (2022)

Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies
por: Guaman-Bautista, Linda P., et al.
Publicado: (2021)

Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design
por: Song, Tian-Qing, et al.
Publicado: (2017)

Precursor-Directed Combinatorial Biosynthesis of Cinnamoyl, Dihydrocinnamoyl, and Benzoyl Anthranilates in Saccharomyces cerevisiae
por: Eudes, Aymerick, et al.
Publicado: (2015)

Rational and combinatorial approaches to engineering styrene production by Saccharomyces cerevisiae
por: McKenna, Rebekah, et al.
Publicado: (2014)

Combinatorial engineering of betalain biosynthesis pathway in yeast Saccharomyces cerevisiae
por: Babaei, Mahsa, et al.
Publicado: (2023)

Standardization of Synthetic Biology Tools and Assembly Methods for Saccharomyces cerevisiae and Emerging Yeast Species
por: Malcı, Koray, et al.
Publicado: (2022)

CRISPR/Cas9‐RNA interference system for combinatorial metabolic engineering of Saccharomyces cerevisiae
por: Kildegaard, Kanchana Rueksomtawin, et al.
Publicado: (2019)

Combinatorial Metabolic Engineering in Saccharomyces cerevisiae for the Enhanced Production of the FPP-Derived Sesquiterpene Germacrene
por: Bröker, Jan Niklas, et al.
Publicado: (2020)

Crocetin Overproduction in Engineered Saccharomyces cerevisiae via Tuning Key Enzymes Coupled With Precursor Engineering
por: Song, Tianqing, et al.
Publicado: (2020)

Fumaric Acid Production in Saccharomyces cerevisiae by In Silico Aided Metabolic Engineering
por: Xu, Guoqiang, et al.
Publicado: (2012)

Comparative Proteomics Analysis of Engineered Saccharomyces cerevisiae with Enhanced Biofuel Precursor Production
por: Tang, Xiaoling, et al.
Publicado: (2013)

Engineering Saccharomyces cerevisiae for the Overproduction of β-Ionone and Its Precursor β-Carotene
por: López, Javiera, et al.
Publicado: (2020)

Inferring combinatorial regulation of transcription in silico
por: Blüthgen, Nils, et al.
Publicado: (2005)

Production of 2,3-butanediol in Saccharomyces cerevisiae by in silico aided metabolic engineering
por: Ng, Chiam Yu, et al.
Publicado: (2012)

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol
por: Mutanda, Ishmael, et al.
Publicado: (2021)

Taxol binds to cellular microtubules
Publicado: (1982)

Toward in Silico Modeling of Dynamic Combinatorial Libraries
por: Casciuc, Iuri, et al.
Publicado: (2022)

High Divergence of the Precursor Peptides in Combinatorial Lanthipeptide Biosynthesis
por: Zhang, Qi, et al.
Publicado: (2014)

Combinatorial library design for improving isobutanol production in Saccharomyces cerevisiae
por: Gambacorta, Francesca V., et al.
Publicado: (2022)

Systematic Analysis of the Anticancer Agent Taxol-Producing Capacity in Colletotrichum Species and Use of the Species for Taxol Production
por: Choi, Jinhee, et al.
Publicado: (2016)

Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects
por: El-Sayed, Ashraf S. A., et al.
Publicado: (2020)

Combinatorial engineering of decomposable systems
por: Levin, Mark Sh
Publicado: (1998)

Combinatorial Engineering of Dextransucrase Specificity
por: Irague, Romain, et al.
Publicado: (2013)

Inhibition of neurite initiation and growth by taxol
Publicado: (1984)

Taxol binds to polymerized tubulin in vitro
por: Parness, J, et al.
Publicado: (1981)

Taxol(®): The First Microtubule Stabilizing Agent
por: Yang, Chia-Ping Huang, et al.
Publicado: (2017)

Insights into Taxol® biosynthesis by endophytic fungi
por: Subban, Kamalraj, et al.
Publicado: (2023)

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol
por: Zhou, Ming, et al.
Publicado: (2010)

Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma
por: FENG, LIN, et al.
Publicado: (2015)

Engineering Isoprenoid Biosynthesis in Artemisia annua L. for the Production of Taxadiene: A Key Intermediate of Taxol
por: Li, Meiya, et al.
Publicado: (2015)

Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production
por: Abdallah, Ingy I., et al.
Publicado: (2019)

Enhancing Saccharomyces cerevisiae Taxane Biosynthesis and Overcoming Nutritional Stress-Induced Pseudohyphal Growth
por: Walls, Laura Ellen, et al.
Publicado: (2022)

Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae
por: Scalcinati, Gionata, et al.
Publicado: (2012)

Optimization of Taxol Extraction Process Using Response Surface Methodology and Investigation of Temporal and Spatial Distribution of Taxol in Taxus mairei
por: Li, Lingyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0qjsr9msb7psbrjapmtlihir36