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Intrinsic Solubility of Ionizable Compounds from pK(a) Shift
[Image: see text] Aqueous solubility of pharmaceutical substances plays an important role in small molecule drug discovery and development, with ionizable groups often employed to enhance solubility. Drug candidate compounds often contain ionizable groups to increase their solubility. Recognizing th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688098/ https://www.ncbi.nlm.nih.gov/pubmed/38046347 http://dx.doi.org/10.1021/acsomega.3c04071 |