Cargando…

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts

Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression. Currently, most of our understanding of SNCA regulation is protein-b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kattan, Fedon-Giasin, Koukouraki, Pelagia, Anagnostopoulos, Athanasios K., Tsangaris, George T., Doxakis, Epaminondas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688287/ https://www.ncbi.nlm.nih.gov/pubmed/37989221 http://dx.doi.org/10.1098/rsob.230158

Ejemplares similares

Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors
por: Ravanidis, Stylianos, et al.
Publicado: (2018)

Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region
por: Koukouraki, Pelagia, et al.
Publicado: (2016)

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP
por: Fragkouli, Apostolia, et al.
Publicado: (2017)

In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome
por: Gourdomichali, Olga, et al.
Publicado: (2022)

APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome
por: Naki, Marianna, et al.
Publicado: (2022)

miRNA Regulons Associated with Synaptic Function
por: Paschou, Maria, et al.
Publicado: (2012)

RNA-Binding Proteins Implicated in Mitochondrial Damage and Mitophagy
por: Ravanidis, Stylianos, et al.
Publicado: (2020)

Principles of miRNA-Target Regulation in Metazoan Models
por: Doxakis, Epaminondas
Publicado: (2013)

Insights into the multifaceted role of circular RNAs: implications for Parkinson’s disease pathogenesis and diagnosis
por: Doxakis, Epaminondas
Publicado: (2022)

NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells
por: Kumar, Vikas, et al.
Publicado: (2022)

Neurofibromin 1 Is a miRNA Target in Neurons
por: Paschou, Maria, et al.
Publicado: (2012)

miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway
por: Fragkouli, Apostolia, et al.
Publicado: (2014)

Serum amyloid-p (SAP), a potential biomarker for Down syndrome fetuses prevention in maternal plasma
por: Anagnostopoulos, Athanasios, et al.
Publicado: (2014)

Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
por: Alfano, Luigi, et al.
Publicado: (2019)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

The Pediatric Ependymoma Protein Database (PEPD)
por: Tsangaris, George Th., et al.
Publicado: (2017)

Feta cheese proteins: Manifesting the identity of Greece׳s National Treasure
por: Anagnostopoulos, Athanasios K., et al.
Publicado: (2018)

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2
por: Latorre, Eva, et al.
Publicado: (2018)

PFDN2 promotes cell cycle progression via the hnRNPD-MYBL2 axis in gastric cancer
por: He, Qiuming, et al.
Publicado: (2023)

CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer
por: Lu, Ya, et al.
Publicado: (2023)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD
por: Jeffery, Nicola, et al.
Publicado: (2021)

Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
por: Barrie, Elizabeth S., et al.
Publicado: (2018)

Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein
por: Yanai, Mako, et al.
Publicado: (2017)

Nuclear Export of L-Periaxin, Mediated by Its Nuclear Export Signal in the PDZ Domain
por: Shi, Yawei, et al.
Publicado: (2014)

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals
por: Fung, Ho Yee Joyce, et al.
Publicado: (2017)

Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects
por: Li, Shirong, et al.
Publicado: (2023)

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
por: Duan, Lauren, et al.
Publicado: (2022)

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
por: Kiely, Aoife P., et al.
Publicado: (2015)

Nuclear Export of Messenger RNA
por: Katahira, Jun
Publicado: (2015)

LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells
por: Lin, Jiajie, et al.
Publicado: (2022)

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease
por: Luo, Ningdi, et al.
Publicado: (2019)

Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA
por: Li, Yuanyuan, et al.
Publicado: (2017)

Prognostic significance of SNCA and its methylation in bladder cancer
por: Wu, Zhengcun, et al.
Publicado: (2022)

Neuronal SNCA transcription during Lewy body formation
por: Kon, Tomoya, et al.
Publicado: (2023)

WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
por: Iglesias-Pedraz, Juan Manuel, et al.
Publicado: (2020)

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export
por: Li, Di, et al.
Publicado: (2020)

Inhibition of Host Gene Expression by KSHV: Sabotaging mRNA Stability and Nuclear Export
por: Pardamean, Carissa Ikka, et al.
Publicado: (2021)

Reconstitution of nuclear protein export in isolated nuclear envelopes
por: Siebrasse, Jan Peter, et al.
Publicado: (2002)

Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site
por: Lee, Yoonji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3n2sf6vni5e35bd33sult269j3