Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease

BACKGROUND: Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer’s disease (AD), Parkinson’s disease (PD), and lysosomal storage disorders (LSDs). Recently, the loss of PGRN was shown to result...

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Detalles Bibliográficos
Autores principales: Gillett, Drew A., Wallings, Rebecca L., Uriarte Huarte, Oihane, Tansey, Malú Gámez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688479/
https://www.ncbi.nlm.nih.gov/pubmed/38037070
http://dx.doi.org/10.1186/s12974-023-02965-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688479/
https://www.ncbi.nlm.nih.gov/pubmed/38037070
http://dx.doi.org/10.1186/s12974-023-02965-w

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