Preferential selection of viral escape mutants by CD8(+) T cell ‘sieving’ of SIV reactivation from latency

HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8(+) T cells may act to prevent early events in viral reactivation. However, the presence of viral immune escape mutations may limit the effect of CD8(+) T cells on viral rebound. Here, we studied the impact of C...

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Detalles Bibliográficos
Autores principales: Docken, Steffen S., McCormick, Kevin, Pampena, M. Betina, Samer, Sadia, Lindemuth, Emily, Pinkevych, Mykola, Viox, Elise G., Wu, Yuhuang, Schlub, Timothy E., Cromer, Deborah, Keele, Brandon F., Paiardini, Mirko, Betts, Michael R., Bar, Katharine J., Davenport, Miles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688670/
https://www.ncbi.nlm.nih.gov/pubmed/38032851
http://dx.doi.org/10.1371/journal.ppat.1011755

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