Cargando…

The indole motif is essential for the antitrypanosomal activity of N(5)-substituted paullones

Severe infections with potentially fatal outcomes are caused by parasites from the genera Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote areas in the tropics and subtropics with limited access to adequate health care. Besides insufficient diagnostics, treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ihnatenko, Irina, Müller, Marco J., Orban, Oliver C. F., Lindhof, Jens C., Benítez, Diego, Ortíz, Cecilia, Dibello, Estefanía, Seidl, Leonardo L., Comini, Marcelo A., Kunick, Conrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688702/ https://www.ncbi.nlm.nih.gov/pubmed/38032881 http://dx.doi.org/10.1371/journal.pone.0292946

Ejemplares similares

Mechanistic and biological characterisation of novel N(5)-substituted paullones targeting the biosynthesis of trypanothione in Leishmania
por: Medeiros, Andrea, et al.
Publicado: (2020)

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
por: Aksenov, Dmitrii A., et al.
Publicado: (2023)

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors
por: Lechner, Christian, et al.
Publicado: (2019)

Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents
por: Pazos, Mariana, et al.
Publicado: (2022)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro
por: Wube, Abraham, et al.
Publicado: (2014)

Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds
por: Alkhaldi, Abdulsalam AM, et al.
Publicado: (2019)

Structural and antitrypanosomal data of different carbasones of piperitone
por: Sakirigui, Amoussatou, et al.
Publicado: (2016)

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
por: Meine, Rosanna, et al.
Publicado: (2018)

Histone deacetylases as targets for antitrypanosomal drugs
por: Zuma, Aline A, et al.
Publicado: (2018)

Antitrypanosomal butanolides from Aiouea trinervis
por: Nunes, Felipe Oliveira, et al.
Publicado: (2020)

Enantiospecific antitrypanosomal in vitro activity of eflornithine
por: Boberg, Mikael, et al.
Publicado: (2021)

The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization
por: Vesković, Ana, et al.
Publicado: (2022)

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
por: Zhang, Ning, et al.
Publicado: (2018)

Combatting Persister Cells With Substituted Indoles
por: Song, Sooyeon, et al.
Publicado: (2020)

Optical properties of 3-substituted indoles
por: Kumar, Jagdeep, et al.
Publicado: (2020)

Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus
por: Pinto, Erika Gracielle, et al.
Publicado: (2014)

Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
por: Martínez-Luis, Sergio, et al.
Publicado: (2012)

Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis
por: Dofuor, Aboagye Kwarteng, et al.
Publicado: (2021)

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity
por: Kimani, Njogu M., et al.
Publicado: (2019)

Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism
por: Pieretti, Simone, et al.
Publicado: (2013)

Antitrypanosomal Activity of Novel Benzaldehyde-Thiosemicarbazone Derivatives from Kaurenoic Acid (†)
por: Haraguchi, Shirani K., et al.
Publicado: (2011)

In-silico Investigation of Antitrypanosomal Phytochemicals from Nigerian Medicinal Plants
por: Setzer, William N., et al.
Publicado: (2012)

Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents
por: Wang, Jiayi, et al.
Publicado: (2014)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds
por: Papadopoulou, Maria V., et al.
Publicado: (2016)

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity
por: Papadopoulou, Maria V., et al.
Publicado: (2016)

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
por: Wall, Richard J., et al.
Publicado: (2018)

Cymantrenyl-Nucleobases: Synthesis, Anticancer, Antitrypanosomal and Antimicrobial Activity Studies
por: Jabłoński, Artur, et al.
Publicado: (2017)

Isolation and Antitrypanosomal Characterization of Furoquinoline and Oxylipin from Zanthoxylum zanthoxyloides
por: Dofuor, Aboagye Kwarteng, et al.
Publicado: (2020)

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium
por: Zheoat, Ahmed M., et al.
Publicado: (2021)

Synthesis and evaluation of the in vitro and in vivo antitrypanosomal activity of 2-styrylquinolines
por: Espinosa, Roger, et al.
Publicado: (2021)

Antineoplastic and Antitrypanosomal Properties of Propolis from Tetragonula biroi Friese
por: Alanazi, Samyah
Publicado: (2022)

Use of Nanocarriers Containing Antitrypanosomal Drugs for the Treatment of Chagas Disease
por: Paiva, Diogo de Freitas, et al.
Publicado: (2023)

In Vitro Antioxidant and Antitrypanosomal Activities of Extract and Fractions of Terminalia catappa
por: de Araújo, Sandra Alves, et al.
Publicado: (2023)

Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents
por: Sola, Irene, et al.
Publicado: (2016)

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity
por: Kimani, Njogu M., et al.
Publicado: (2018)

Complementary Quantitative Structure–Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones
por: Kimani, Njogu M., et al.
Publicado: (2018)

Design, Synthesis and Biological Activity of C3 Hemisynthetic Triterpenic Esters as Novel Antitrypanosomal Hits
por: Schioppa, Laura, et al.
Publicado: (2021)

Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae)
por: Santos, Luciana de Á., et al.
Publicado: (2015)

Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent
por: Carothers, Simira, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1gee1ka1ookdg66tfch8u880t2