Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1

Many cancers harbor homologous recombination defects (HRDs). A HRD is a therapeutic target that is being successfully utilized in treatment of breast/ovarian cancer via synthetic lethality. However, canonical HRD caused by BRCAness mutations do not prevail in liver cancer. Here we report a subtype o...

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Detalles Bibliográficos
Autores principales: Zeng, Ming, Tang, Zizhi, Ren, Laifeng, Wang, Haibin, Wang, Xiaojun, Zhu, Wenyuan, Mao, Xiaobing, Li, Zeyang, Mo, Xianming, Chen, Jun, Han, Junhong, Kong, Daochun, Ji, Jianguo, Carr, Antony M., Liu, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688980/
https://www.ncbi.nlm.nih.gov/pubmed/37815873
http://dx.doi.org/10.1172/JCI171533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688980/
https://www.ncbi.nlm.nih.gov/pubmed/37815873
http://dx.doi.org/10.1172/JCI171533

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