CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1–positive regulator for tumor immune evasion

Regulation of tumoral PD-L1 expression is critical to advancing our understanding of tumor immune evasion and the improvement of existing antitumor immunotherapies. Herein, we describe a CRISPR-based screening platform and identified ATXN3 as a positive regulator for PD-L1 transcription. TCGA databa...

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Detalles Bibliográficos
Autores principales: Wang, Shengnan, Iyer, Radhika, Han, Xiaohua, Wei, Juncheng, Li, Na, Cheng, Yang, Zhou, Yuanzhang, Gao, Qiong, Zhang, Lingqiang, Yan, Ming, Sun, Zhaolin, Fang, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688982/
https://www.ncbi.nlm.nih.gov/pubmed/38038129
http://dx.doi.org/10.1172/JCI167728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688982/
https://www.ncbi.nlm.nih.gov/pubmed/38038129
http://dx.doi.org/10.1172/JCI167728

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