Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D c...

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Detalles Bibliográficos
Autores principales: Cruz-Acuña, Ricardo, Kariuki, Secunda W., Sugiura, Kensuke, Karaiskos, Spyros, Plaster, Eleanor M., Loebel, Claudia, Efe, Gizem, Karakasheva, Tatiana, Gabre, Joel T., Hu, Jianhua, Burdick, Jason A., Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688988/
https://www.ncbi.nlm.nih.gov/pubmed/37788109
http://dx.doi.org/10.1172/JCI168146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688988/
https://www.ncbi.nlm.nih.gov/pubmed/37788109
http://dx.doi.org/10.1172/JCI168146

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