The N-terminal peptide of the main protease of SARS-CoV-2, targeting dimer interface, inhibits its proteolytic activity

The main protease (Mpro) of SARS-CoV-2 cleaves 11 sites of viral polypeptide chains and generates essential non-structural proteins for viral replication. Mpro is an important drug target against COVID-19. In this study, we developed a real-time fluorometric turn-on assay system to evaluate Mpro pro...

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Detalles Bibliográficos
Autores principales: Song, Sunyu, Kim, Yeseul, Kwak, Kiwoong, Lee, Hyeonmin, Park, Hyunjae, Kim, Young Bong, Lee, Hee-Jung, Kang, Lin-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689081/
https://www.ncbi.nlm.nih.gov/pubmed/37817441
http://dx.doi.org/10.5483/BMBRep.2023-0153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689081/
https://www.ncbi.nlm.nih.gov/pubmed/37817441
http://dx.doi.org/10.5483/BMBRep.2023-0153

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