Cryo-EM of Aβ fibrils from mouse models find tg-APP(ArcSwe) fibrils resemble those found in patients with sporadic Alzheimer’s disease

The use of transgenic mice displaying amyloid-β (Aβ) brain pathology has been essential for the preclinical assessment of new treatment strategies for Alzheimer’s disease. However, the properties of Aβ in such mice have not been systematically compared to Aβ in the brains of patients with Alzheimer’...

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Detalles Bibliográficos
Autores principales: Zielinski, Mara, Peralta Reyes, Fernanda S., Gremer, Lothar, Schemmert, Sarah, Frieg, Benedikt, Schäfer, Luisa U., Willuweit, Antje, Donner, Lili, Elvers, Margitta, Nilsson, Lars N. G., Syvänen, Stina, Sehlin, Dag, Ingelsson, Martin, Willbold, Dieter, Schröder, Gunnar F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689242/
https://www.ncbi.nlm.nih.gov/pubmed/37973869
http://dx.doi.org/10.1038/s41593-023-01484-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689242/
https://www.ncbi.nlm.nih.gov/pubmed/37973869
http://dx.doi.org/10.1038/s41593-023-01484-4

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