Phospho-Ser727 triggers a multistep inactivation of STAT3 by rapid dissociation of pY705–SH2 through C-terminal tail modulation

Signal transducer and activator of transcription 3 (STAT3) is involved in many biological processes, including immunity and cancer. STAT3 becomes phosphorylated at Tyr705 and Ser727 on IL-6 stimulation. Phospho-Tyr705 (pY705) stabilizes the STAT3 dimer with reciprocal interactions between pY705 and...

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Detalles Bibliográficos
Autores principales: Yang, Junhao, Kunimoto, Hiroyuki, Katayama, Bumpei, Zhao, Hong, Shiromizu, Takashi, Wang, Lingyu, Ozawa, Toshiyuki, Tomonaga, Takeshi, Tsuruta, Daisuke, Nakajima, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689346/
https://www.ncbi.nlm.nih.gov/pubmed/31555812
http://dx.doi.org/10.1093/intimm/dxz061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689346/
https://www.ncbi.nlm.nih.gov/pubmed/31555812
http://dx.doi.org/10.1093/intimm/dxz061

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