The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment

Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well characterized, is also the least favorable, with a survival rate of 50%. Current treatments, based on surgery, radiotherapy, and chemotherapy,...

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Detalles Bibliográficos
Autores principales: Contenti, J., Guo, Y., Mazzu, A., Irondelle, M., Rouleau, M., Lago, C., Leva, G., Tiberi, L., Ben-Sahra, I., Bost, F., Mazure, N. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689432/
https://www.ncbi.nlm.nih.gov/pubmed/38036520
http://dx.doi.org/10.1038/s41419-023-06275-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689432/
https://www.ncbi.nlm.nih.gov/pubmed/38036520
http://dx.doi.org/10.1038/s41419-023-06275-0

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